Honey/polymeric nanofiber enriched with clove (Syzygium aromaticum L.) extract and Al2O3 nanoparticles: Antibacterial and in vitro wound healing studies

The natural extract of Caryophyllus aromaticus (clove) and aluminum oxide nanoparticles (NPs) was packed in honey/chitosan (HTCs) to manufacturing biocompatible antibacterial nanofibrous wound bandage. This work will compare two types agents, the first is a which clove extracted from aromaticus, second metal nanoparticles, are 0xide nanoparticles. (CE) NPs (Al2O3 NPs) enriched HTCs prepare HTCs-CE, HTCs-Al2O3NPs, HTCs-CE/Al2O3 nanofibers mates respectively. All prepared mats were characterized using field emission scanning electron microscopy (FESEM). In vitro, testing against S. aureus, P. aeruginosa, vulgaris, s. pyogenes carrying out comparison with Meropenem Imipenem antibiotics. MTT assay used for evaluation cell viability proliferation developed nanofibers. result appears that all HTCs, HTCs-CE/Al2O3NPs treatments have different ability inhibit bacterial growth depend on types. These showed significantly greater efficiency inhibition as compared mentioned 0n other hand, culture studies proved nanofiber good biocompatibility commercial Aquacel®Ag. results indicated become more effective control. Moreover, significant effects dressing